X-ray crystallography to cryo-electron microscopy: computing infrastructure in structural biology
نویسندگان
چکیده
منابع مشابه
Complementing crystallography: the role of cryo-electron microscopy in structural biology.
Dramatic improvements in experimental methods and computational techniques have revolutionized three-dimensional image reconstruction from electron micrographs (EM) of vitrified samples. Recent results include the first determination of a protein fold (for the core protein of the hepatitis B virus) by non-crystalline imaging techniques. These developments have generated interest within the crys...
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When the electron microscope was conceived in the early 1950s, it was originally to be a tool mainly for atomic physicists who were interested in obtaining more detailed analyses of materials such as metals at an atomic resolution. Using a beam of electrons rather than a beam of light, it would be possible to gain the sufficient resolution needed to visualize the comparatively much larger nucle...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2018
ISSN: 2053-2733
DOI: 10.1107/s2053273318089003